BMJ Oncology: 3 (1)

Matthew E Barclay, Cristina Renzi, Hannah Harrison, Ana Torralbo, Becky White, Samantha Hiu Yan Ip, Juliet Usher-Smith, Jane Lange, Nora Pashayan, Spiros Denaxas, Angela M Wood, Antonis Antoniou, Georgios Lyratzopoulos

13 November 2024• open access icon

Enhanced immune responses are accompanied by increased MAGEA expression in osteosarcoma metastases

Debora M Meijer, Siddh van Oost, Jessica P Roelands, Dina Ruano, I H Briaire-de Bruijn, B E van den Akker, A B Kruisselbrink, P M Wijers-Koster, Manon van der Ploeg, Marieke Ijsselsteijn, S W Lam, Arnoud H de Ru, R T N Tjokrodirijo, M A J van de Sande, Hans Gelderblom, Peter A Van Veelen, M L Kuijjer, Noel de Miranda, Judith V M G Bovee

2 November 2024• open access icon

From prediction to practice: mitigating bias and data shift in machine-learning models for chemotherapy-induced organ dysfunction across unseen cancers

Matthew Watson, Pinkie Chambers, Luke Steventon, James Harmsworth King, Angelo Ercia, Heather Shaw, Noura Al Moubayed

18 September 2024• open access icon

Associations between socioeconomic factors and PSA testing in a population-based organised testing programme and routine healthcare: a register-based study of 50-year-old men

Emil Järbur, Erik Holmberg, Thomas Björk-Eriksson, Ola Bratt, Rebecka Arnsrud Godtman

29 August 2024• open access icon

UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOASTIE study

Mark A Baxter, Michael Rowe, Kieran Zucker, Adam L Peters, Maria Rohan, Alexandra Marsh, Abigail L Gee, Gemma Quesne, Jonny Heseltine, Rachel Prichard, Deborah Scott, Conor O'Neill, Clair Brunner, Joni Howells, Veronica Conteh, Avinash Aujayeb, Xiangfei Yan, Lisa J Rodgers, Sally Martin, Helen Dearden

22 August 2024• open access icon

Increase in major osteoporotic fractures after therapy with immune checkpoint inhibitors

Carrie Ye, Bo Zhao, William D Leslie, Juan Ignacio Ruiz, Hui Zhao, Noha Abdel-Wahab, Maria E Suarez-Almazor

21 August 2024• open access icon

Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer

Zhenhua Liu, Ke Ma, Qingzhu Jia, Yunpeng Yang, Peng Fan, Ying Wang, Junhui Wang, Jiya Sun, Liansai Sun, Hongtai Shi, Liang Sun, Bo Zhu, Wei Xu, Li Zhang, Rakesh K. Jain, Songbing Qin, Yuhui Huang

14 August 2024• open access icon

As bleak as it sounds? Analysing trends in oncology clinical trial initiation in the UK from 2010 to 2022

Alexander David VanHelene, Matthew J Hadfield, Dario Trapani, Jeremy Lyle Warner, Mark P Lythgoe

13 August 2024• open access icon

Prospective comparative study of quality of life in patients with bladder cancer undergoing cystectomy with ileal conduit or bladder preservation

Vedang Murthy, Sheetal R Kashid, Mahendra Pal, Alvina Vadassery, Priyamvada Maitre, Amandeep Arora, Pallavi Singh, Amit Joshi, Ganesh Bakshi, Gagan Prakash

12 August 2024• open access icon

Under-representation of older Indian persons with cancer in clinical trials

Vanita Noronha, Vijay Patil, Nandini Menon, Manali Kolkur, Zoya Peelay, Minit Shah, Vijayalakshmi Mathrudev, Srushti Shah, Kavita Nawale, Nita S Nair, Anant Ramaswamy, Vikas Ostwal, Sarbani Ghosh-Laskar, Jai Prakash Agarwal, Pankaj Chaturvedi, Supriya Chopra, Vedang Murthy, Sheila N Myatra, Jigeeshu Divatia, Vikram Gota, Sudeep Gupta, Vikram Chaudhari, Sabita Jiwnani, Shailesh V Shrikhande, Richa Vaish, Devendra Chaukar, Shivakumar Thiagarajan, Sudhir Nair, Anil D'Cruz, Amey Oak, Rohini Hawaladar, Oindrila Roy Chowdhury, Shripad Banavali, Rajendra Badwe, Kumar Prabhash

12 August 2024• open access icon

Cancer burden across the South Asian Association for Regional Cooperation in 2022

Urvish Jain, Faraan Rahim, Bhav Jain, Abhinav Komanduri, Aditya Arkalgud, Cameron John Sabet, Alessandro Hammond, Phub Tshering, Tej A Patel, Bhawna Sirohi, Pankaj Jain, Shah Zeb Khan, Sanjeeva Gunasekera, Ramila Shilpakar, Zabihullah Stanikzai, Arman Reza Chowdhury, Nishwant Swami, Edward Christopher Dee, Bishal Gyawali

8 August 2024• open access icon

Association of pre-existing cardiovascular disease with administration of fluoropyrimidine chemotherapy in patients with gastrointestinal malignancies

Aderonke Temilade Abiodun, Chengsheng Ju, Catherine A Welch, Jennifer Lai, Freya Tyrer, Pinkie Chambers, Lizz Paley, Sally Vernon, John Deanfield, Mark de Belder, Mark Rutherford, Paul C Lambert, Sarah Slater, Kai Keen Shiu, Li Wei, Michael D Peake, , David Adlam, Charlotte Manisty

8 August 2024• open access icon

Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy

Lisanne Renting, Nienke R K Zwart, Per Magne Ueland, Adrian McCann, Arve Ulvik, Henk K van Halteren, Floor J E Lubberman, Renate M Winkels, Ellen Kampman, Dieuwertje E Kok

7 August 2024• open access icon

Choosing Wisely in oncology: are guidelines effective at preventing unnecessary diagnostics? The example of surveillance positron emission tomography for patients with localised colorectal cancer

Daniel A Goldstein, Roi Tschernichovsky, Talish Razi, Keren Filosof, Idan Menashe, Ronen Arbel, Doron Netzer

6 August 2024• open access icon

Preconsultation compassion video to reduce anxiety among patients referred to a cancer centre: a randomised control trial

Christine Winn, Generosa Grana, Anthony Mazzarelli, Andrea Nicholson, Kristine Mykulowycz, Chidinma Obiakor, Alicia Bair, Stephen Trzeciak, Brian Roberts

6 August 2024• open access icon

Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy

Sanghee Cho, Elizabeth McDonough, John Graf, Jinru Shia, Canan Firat, Nil Urganci, Christine Surrette, Andreas Lindner, Manuela Salvucci, Anna Matveeva, Batuhan Kisakol, Anthony O’Grady, Mohammadreza Azimi, John P Burke, Deborah A McNamara, Simon McDade, Daniel B Longley, Jochen HM Prehn, Fiona Ginty

30 July 2024• open access icon

Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch repair-deficient colorectal cancer

Chad Tang, Genevieve P Hartley, Coline Couillault, Ying Yuan, Heather Lin, Courtney Nicholas, Anupallavi Srinivasamani, James Dai, Ecaterina E Ileana Dumbrava, Siqing Fu, Daniel D Karp, Aung Naing, Sarina A Piha-Paul, Jordi Rodon Ahnert, Shubham Pant, Vivek Subbiah, Timonthy A Yap, Apostolia M Tsimberidou, Paola Guerrero, Sarah Dhebat, Theresa Proia, Michael A Curran, David S Hong

29 July 2024• open access icon

Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study

Laurence J Glancz, Cathal John Hannan, Alexandros Vyziotis, Gillian M Potter, Rekha Siripurapu, Raj K Bhalla, Scott A Rutherford, Andrew Thomas King, Charlotte Hammerbeck-Ward, Adrian Crellin, Shermaine Pan, Rovel Colaco, Gillian A Whitfield, Omar N Pathmanaban

20 July 2024• open access icon

Novel machine learning algorithm in risk prediction model for pan-cancer risk: application in a large prospective cohort

Xifeng Wu, Huakang Tu, Qingfeng Hu, Shan Pou Tsai, David Ta-Wei Chu, Chi-Pang Wen

18 July 2024• open access icon

Assessing the rates of false-positive ovarian cancer screenings and surgical interventions associated with screening tools: a systematic review

Sierra M Silverwood, Grant Backer, Annie Galloway, Katrina Reid, Anna Jeter, Margo Harrison

11 July 2024• open access icon

Medhavi Gupta, Othman Salim Akhtar, Bhavyaa Bahl, Angel Mier-Hicks, Kristopher Attwood, Kayla Catalfamo, Bishal Gyawali, Pallawi Torka

5 July 2024• open access icon

Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?

Z L Rana Kaplan, Nikki van Leeuwen, David van Klaveren, Otto Visser, Eduardus F M Posthuma, Danielle van Lammeren-Venema, Tjeerd J F Snijders, Catharina H M J van Elssen, Anna van Rhenen, Peter A von dem Borne, Nicole M A Blijlevens, Jan J Cornelissen, Marc H G P Raaijmakers, Arjan A van de Loosdrecht, Gerwin Huls, Valery E P P Lemmens, Hester F Lingsma, Avinash G Dinmohamed

12 June 2024• open access icon

Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses from the JAVELIN Renal 101 trial

Matthew Tucker, Yu-Wei Chen, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Marc-Oliver Grimm, Paul Nathan, Christian Kollmannsberger, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Mariangela Mariani, Alessandra di Pietro, Brian Rini

30 May 2024• open access icon

Blood-based DNA methylation markers for lung cancer prediction

Justina Ucheojor Onwuka, Florence Guida, Ryan Langdon, Mikael Johansson, Gianluca Severi, Roger L Milne, Pierre-Antoine Dugué, Melissa C Southey, Paolo Vineis, Torkjel Sandanger, Therese Haugdahl Nøst, Marc Chadeau-Hyam, Caroline Relton, Hilary A. Robbins, Matthew Suderman, Mattias Johansson

21 May 2024• open access icon

Patterns of cytotoxic T-cell densities in immunogenic endometrial cancers reveal a potential mechanism for differences in immunotherapy efficacy

Neil Ryan, Mark Glaire, Thomas Walker, Natalja ter Haar, Marieke Ijsselsteijn, James Bolton, Noel de Miranda, Gareth Evans, David N Church, Tjalling Bosse, Emma Crosbie

15 May 2024• open access icon

Exploring the value of routinely collected data on EQ-5D-5L and other electronic patient-reported outcome measures as prognostic factors in adults with advanced non-small cell lung cancer receiving immunotherapy

Kuan Liao, David C Wong, Fabio Gomes, Corinne Faivre-Finn, Laura Moliner, Matthew Sperrin, Janelle Yorke, Sabine N van der Veer

9 May 2024• open access icon

First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours

Aung Naing, Kyriakos P Papadopoulos, Michael J Pishvaian, Osama Rahma, Glenn J Hanna, Elena Garralda, Omar Saavedra, Sven Gogov, Howard Kallender, LuLu Cheng, Michael Smith, Xuejun Chen, Emil Kuriakose, Todd Bauer

8 May 2024• open access icon

Defining national research priorities for prostate cancer in Zambia: using the Delphi process for comprehensive cancer policy setting in sub-Saharan Africa

Dorothy Chilambe Lombe, Monde Mwamba, Musonda Simwinga, Virginia Bond, Andrew Sentoogo Ssemata, Richard Muhumuza, Janet Seeley, Kennedy Lishimpi, Victor Mapulanga, John Kachimba, Ajay Aggarwal, Susan Msadabwe

30 April 2024• open access icon

Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis

Elias B A Chandran, Giovanni Maria Iannantuono, Saad O Atiq, Dilara Akbulut, Ninet Sinaii, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Amin H Nassar, Jonathan E Rosenberg, Gisela Butera, Min Yuen Teo, Guru Sonpavde, Jonathan A Coleman, Andrea B Apolo

18 April 2024• open access icon

Sex and authorship in global cancer research

Miriam Mutebi, Grant Lewison, Deborah Mukherji, Nazik Hammad, Verna Vanderpuye, Erica Liebermann, Winnie K W So, Julie Torode, Richard Sullivan, Ophira Ginsburg

11 April 2024• open access icon

Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials

Alexander D Sherry, Pavlos Msaouel, Timothy A Lin, Joseph Abi Jaoude, Ramez Kouzy, Esther J Beck, Avital M Miller, Adina H Passy, Gabrielle S Kupferman, Eugene J Koay, Clifton David Fuller, Charles R Thomas, Zachary R McCaw, Ethan B Ludmir

8 April 2024• open access icon

Characterisation of clinical response and transcriptional profiling of proliferating CD8 T cells in the blood of cancer patients after PD-1 monotherapy or combination therapy

Rebecca C Obeng, Tahseen H Nasti, Kylee Martens, Peng Li, Annapaola Mariniello, Daniel Y Chang, Christiane S Eberhardt, Donald McGuire, Haydn Kissick, Candace Daugherty, Yuzi Zhang, Andreas Wieland, Zhengjia Chen, Jeffrey M Switchenko, Rathi Pillai, Alice O Kamphorst, Warren J Leonard, Rafi Ahmed, Suresh S Ramalingam

3 April 2024• open access icon

Tale of two zones: investigating the clinical outcomes and research gaps in peripheral and transition zone prostate cancer through a systematic review and meta-analysis

Amin Ali, Thiraviyam Elumalai, BhanuPrasad Venkatesulu, Lauren Hekman, Hitesh Mistry, Ashwin Sachdeva, Pedro Oliveira, Noel Clarke, Esther Baena, Ananya Choudhury, Robert G Bristow

19 March 2024• open access icon

Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials

Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Ryan McIntire, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia, Alyson Haslam, Vinay Prasad, Matt Vassar

13 March 2024• open access icon

Feasibility of implementing a rapid-learning methodology to inform radiotherapy treatments: key professional stakeholders’ views

Arbaz Kapadi, Gareth Price, Corinne Faivre-Finn, Rebecca Holley, Kate Wicks, Kathryn Banfill, Gareth Webster, Kevin Franks, Fiona McDonald, Daniel Johnson, David P French

12 March 2024• open access icon

Challenges faced by women oncologists in Africa: a mixed methods study

Miriam Mutebi, Naa Adorkor Aryeetey, Haimanot Kasahun Alemu, Laura Carson, Zainab Mohamed, Zainab Doleeb, Nwamaka Lasebikan, Nazima Jaffer Dharsee, Susan Msadabwe, Doreen Ramogola-Masire, Sitna Mwanzi, Khadija Warfa, Emmanuella Nwachukwu, Edom Seife Woldetsadik, Hirondina Vaz Borges Spencer, Nesrine Chraiet, Matthew Jalink, Reshma Jagsi, Dorothy Chilambe Lombe, Verna Vanderpuye, Nazik Hammad

29 February 2024• open access icon

Comparison of standard-dose and reduced-dose treatment of metastatic prostate cancer with enzalutamide, apalutamide or darolutamide: a rapid review

Hannah Louise Bromley, Mohini Varughese, Duncan C Gilbert, Peter Hoskin, Ian F Tannock, Kimberley Reeves, Ananya Choudhury

10 February 2024• open access icon

Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia

Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Marie Roumet, Andreas Limacher, Herbert Kapesa, Thamsanqa Madliwa, Anne Rutjes, Partha Basu, Nicola Low, Albert Manasyan, Julia Bohlius

1 February 2024• open access icon

Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy

Jian-Guo Zhou, Jie Yang, Haitao Wang, Ada Hang-Heng Wong, Fangya Tan, Xiaofei Chen, Si-Si He, Gang Shen, Yun-Jia Wang, Benjamin Frey, Rainer Fietkau, Markus Hecht, Wenzhao Zhong, Hu Ma, Udo Gaipl

30 January 2024• open access icon

Pharmacological class effects of anticancer drugs: opportunities for decreasing healthcare spending

Daniel A Goldstein, Leonard B Saltz, Gregory R Pond, Ian F Tannock

9 January 2024• open access icon

Novel proteomics-based plasma test for early detection of multiple cancers in the general population

Bogdan Budnik, Hossein Amirkhani, Mohammad H Forouzanfar, Ashkan Afshin

Review

2 October 2024• open access icon

Bedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more

Timothée Olivier, Alyson Haslam, Dagney Ochoa, Eduardo Fernandez, Vinay Prasad

10 September 2024• open access icon

Circulating tumour cell clusters: isolation, biological significance and therapeutic implications

Yufan Yang, Guanyin Huang, Jingru Lian, Chunhao Long, Boxi Zhao, Xuefei Liu, Binyu Zhang, Weijian Ye, Junhao Chen, Longxiang Du, Zhuofeng Jiang, Jialing Liu, Jianglin Zhang, Chengzhi Hu, Qingfeng Chen, Xin Hong

16 July 2024• open access icon

Association between rheumatoid arthritis and risk of radiotherapy toxicity: a systematic review

Nina Liebenberg, Alan McWilliam, Sarah L Kerns, Deborah C Marshall, Catharine M West

31 May 2024• open access icon

Implications of hormonal carcinogenesis for transgender and gender-diverse people undergoing gender-affirming hormone therapy: an up-to-date review

Alberto Giovanni Leone, Stefania Bonadonna, Chiara Cassani, Amelia Barcellini, Marianna Sirico, Barbara Tagliaferri, Stefano Maccarone, Davide Dalu, Lorenzo Ruggieri, Filippo Ghelardi, Matteo Lambertini, Simone Nardin, Rossana Berardi, Nicla La Verde, Francesco Perrone, Saverio Cinieri, Dario Trapani, Filippo Pietrantonio

10 May 2024• open access icon

Prospective evaluation of artificial intelligence (AI) applications for use in cancer pathways following diagnosis: a systematic review

Sheba Macheka, Peng Yun Ng, Ophira Ginsburg, Andrew Hope, Richard Sullivan, Ajay Aggarwal

1 March 2024• open access icon

HealthCare Access Barrier (HCAB) framework for the barriers to cancer care during conflicts: perspective from Iraq

Kouther Mohsin, Layth Mula-Hussain, Richard Gilson

1 February 2024• open access icon

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity

Brian M Ortmann

17 January 2024• open access icon

Repurposing radiosensitising medicines for radiotherapy: an overview

Jie Man Low, Gonzalo Rodriguez-Berriguete, Geoff S Higgins

17 January 2024• open access icon

Artificial intelligence across oncology specialties: current applications and emerging tools

John Kang, Kyle Lafata, Ellen Kim, Christopher Yao, Frank Lin, Tim Rattay, Harsha Nori, Evangelia Katsoulakis, Christoph Ilsuk Lee