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Current Issue

January 2024 - Volume 3 - 1

Editorial

29 August 2024open access icon
Do shortcuts leave older patients short changed? The UK TOASTIE study
Richard Simcock, Nicolò Matteo Luca Battisti
12 August 2024open access icon
Geriatric oncology in LMICs: it is time to mature
Amol Akhade, Haydee Verduzco-Aguirre, Bishal Gyawali
7 August 2024open access icon
Recall of ibrutinib and issues with therapeutic approval
Colton Lipfert, Myung Sun Kim, Alyson Haslam, Vinay K Prasad
30 April 2024open access icon
Uncovering the role of mismatch repair deficiency and microsatellite instability in urothelial carcinoma
Filippo Ghelardi, Patrizia Giannatempo, Filippo Pietrantonio
13 February 2024open access icon
Identifying the deficits in cancer care for people with intellectual disabilities
Maarten Cuypers, Deborah Cairns, Kathryn A Robb

Original research

2 November 2024open access icon
From prediction to practice: mitigating bias and data shift in machine-learning models for chemotherapy-induced organ dysfunction across unseen cancers
Matthew Watson, Pinkie Chambers, Luke Steventon, James Harmsworth King, Angelo Ercia, Heather Shaw, Noura Al Moubayed
29 August 2024open access icon
UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOASTIE study
Mark A Baxter, Michael Rowe, Kieran Zucker, Adam L Peters, Maria Rohan, Alexandra Marsh, Abigail L Gee, Gemma Quesne, Jonny Heseltine, Rachel Prichard, Deborah Scott, Conor O'Neill, Clair Brunner, Joni Howells, Veronica Conteh, Avinash Aujayeb, Xiangfei Yan, Lisa J Rodgers, Sally Martin, Helen Dearden, , J Grech, L Hannington, S McInerney, S Kingdon, H Ali, L Eastlake, S Park, R Bryce, D Parslow, V Cope, J Hamilton, G Clements, N Aziz, J Platt, R Heywood
22 August 2024open access icon
Increase in major osteoporotic fractures after therapy with immune checkpoint inhibitors
Carrie Ye, Bo Zhao, William D Leslie, Juan Ignacio Ruiz, Hui Zhao, Noha Abdel-Wahab, Maria E Suarez-Almazor
21 August 2024open access icon
Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer
Zhenhua Liu, Ke Ma, Qingzhu Jia, Yunpeng Yang, Peng Fan, Ying Wang, Junhui Wang, Jiya Sun, Liansai Sun, Hongtai Shi, Liang Sun, Bo Zhu, Wei Xu, Li Zhang, Rakesh K. Jain, Songbing Qin, Yuhui Huang
14 August 2024open access icon
As bleak as it sounds? Analysing trends in oncology clinical trial initiation in the UK from 2010 to 2022
Alexander David VanHelene, Matthew J Hadfield, Dario Trapani, Jeremy Lyle Warner, Mark P Lythgoe
13 August 2024open access icon
Prospective comparative study of quality of life in patients with bladder cancer undergoing cystectomy with ileal conduit or bladder preservation
Vedang Murthy, Sheetal R Kashid, Mahendra Pal, Alvina Vadassery, Priyamvada Maitre, Amandeep Arora, Pallavi Singh, Amit Joshi, Ganesh Bakshi, Gagan Prakash
12 August 2024open access icon
Under-representation of older Indian persons with cancer in clinical trials
Vanita Noronha, Vijay Patil, Nandini Menon, Manali Kolkur, Zoya Peelay, Minit Shah, Vijayalakshmi Mathrudev, Srushti Shah, Kavita Nawale, Nita S Nair, Anant Ramaswamy, Vikas Ostwal, Sarbani Ghosh-Laskar, Jai Prakash Agarwal, Pankaj Chaturvedi, Supriya Chopra, Vedang Murthy, Sheila N Myatra, Jigeeshu Divatia, Vikram Gota, Sudeep Gupta, Vikram Chaudhari, Sabita Jiwnani, Shailesh V Shrikhande, Richa Vaish, Devendra Chaukar, Shivakumar Thiagarajan, Sudhir Nair, Anil D'Cruz, Amey Oak, Rohini Hawaladar, Oindrila Roy Chowdhury, Shripad Banavali, Rajendra Badwe, Kumar Prabhash
12 August 2024open access icon
Cancer burden across the South Asian Association for Regional Cooperation in 2022
Urvish Jain, Faraan Rahim, Bhav Jain, Abhinav Komanduri, Aditya Arkalgud, Cameron John Sabet, Alessandro Hammond, Phub Tshering, Tej A Patel, Bhawna Sirohi, Pankaj Jain, Shah Zeb Khan, Sanjeeva Gunasekera, Ramila Shilpakar, Zabihullah Stanikzai, Arman Reza Chowdhury, Nishwant Swami, Edward Christopher Dee, Bishal Gyawali
8 August 2024open access icon
Association of pre-existing cardiovascular disease with administration of fluoropyrimidine chemotherapy in patients with gastrointestinal malignancies
Aderonke Temilade Abiodun, Chengsheng Ju, Catherine A Welch, Jennifer Lai, Freya Tyrer, Pinkie Chambers, Lizz Paley, Sally Vernon, John Deanfield, Mark de Belder, Mark Rutherford, Paul C Lambert, Sarah Slater, Kai Keen Shiu, Li Wei, Michael D Peake, , David Adlam, Charlotte Manisty, , David Adlam, Mick Peake, John Deanfield, Lucy Elliss-Brookes, Mark de Belder, Sarah Darby, Chris Gale, Mike Hawkins, Paul Lambert, Alexander Lyon, Jem Rashbass, Raoul Reulen, Alistair Ring, Mark Rutherford, Michael Sweeting, Adam Timmis, Sally Vernon, Paul Charlton, Sally Jeans, Alison Fielding, Andy Deutsch, James Chal, Akosua Donkor, Nadeem Fazal, Anil Gunesh, Andrew Harrison, Lizz Paley, Brian Shand, Sally Vernon, Jennifer Lai, Abbas Khushnood, Andrew Goodwin, Peter Ludman, Theresa McDonagh, Francis Murgatroyd, Clive Weston
8 August 2024open access icon
Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy
Lisanne Renting, Nienke R K Zwart, Per Magne Ueland, Adrian McCann, Arve Ulvik, Henk K van Halteren, Floor J E Lubberman, Renate M Winkels, Ellen Kampman, Dieuwertje E Kok
6 August 2024open access icon
Preconsultation compassion video to reduce anxiety among patients referred to a cancer centre: a randomised control trial
Christine Winn, Generosa Grana, Anthony Mazzarelli, Andrea Nicholson, Kristine Mykulowycz, Chidinma Obiakor, Alicia Bair, Stephen Trzeciak, Brian Roberts
6 August 2024open access icon
Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy
Sanghee Cho, Elizabeth McDonough, John Graf, Jinru Shia, Canan Firat, Nil Urganci, Christine Surrette, Andreas Lindner, Manuela Salvucci, Anna Matveeva, Batuhan Kisakol, Anthony O’Grady, Mohammadreza Azimi, John P Burke, Deborah A McNamara, Simon McDade, Daniel B Longley, Jochen HM Prehn, Fiona Ginty
30 July 2024open access icon
Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch repair-deficient colorectal cancer
Chad Tang, Genevieve P Hartley, Coline Couillault, Ying Yuan, Heather Lin, Courtney Nicholas, Anupallavi Srinivasamani, James Dai, Ecaterina E Ileana Dumbrava, Siqing Fu, Daniel D Karp, Aung Naing, Sarina A Piha-Paul, Jordi Rodon Ahnert, Shubham Pant, Vivek Subbiah, Timonthy A Yap, Apostolia M Tsimberidou, Paola Guerrero, Sarah Dhebat, Theresa Proia, Michael A Curran, David S Hong
29 July 2024open access icon
Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study
Laurence J Glancz, Cathal John Hannan, Alexandros Vyziotis, Gillian M Potter, Rekha Siripurapu, Raj K Bhalla, Scott A Rutherford, Andrew Thomas King, Charlotte Hammerbeck-Ward, Adrian Crellin, Shermaine Pan, Rovel Colaco, Gillian A Whitfield, Omar N Pathmanaban
20 July 2024open access icon
Novel machine learning algorithm in risk prediction model for pan-cancer risk: application in a large prospective cohort
Xifeng Wu, Huakang Tu, Qingfeng Hu, Shan Pou Tsai, David Ta-Wei Chu, Chi-Pang Wen
18 July 2024open access icon
Assessing the rates of false-positive ovarian cancer screenings and surgical interventions associated with screening tools: a systematic review
Sierra M Silverwood, Grant Backer, Annie Galloway, Katrina Reid, Anna Jeter, Margo Harrison
11 July 2024open access icon
Health-related quality of life outcomes reporting associated with FDA approvals in haematology and oncology
Medhavi Gupta, Othman Salim Akhtar, Bhavyaa Bahl, Angel Mier-Hicks, Kristopher Attwood, Kayla Catalfamo, Bishal Gyawali, Pallawi Torka
5 July 2024open access icon
Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?
Z L Rana Kaplan, Nikki van Leeuwen, David van Klaveren, Otto Visser, Eduardus F M Posthuma, Danielle van Lammeren-Venema, Tjeerd J F Snijders, Catharina H M J van Elssen, Anna van Rhenen, Peter A von dem Borne, Nicole M A Blijlevens, Jan J Cornelissen, Marc H G P Raaijmakers, Arjan A van de Loosdrecht, Gerwin Huls, Valery E P P Lemmens, Hester F Lingsma, Avinash G Dinmohamed
12 June 2024open access icon
Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses from the JAVELIN Renal 101 trial
Matthew Tucker, Yu-Wei Chen, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Marc-Oliver Grimm, Paul Nathan, Christian Kollmannsberger, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Mariangela Mariani, Alessandra di Pietro, Brian Rini
30 May 2024open access icon
Blood-based DNA methylation markers for lung cancer prediction
Justina Ucheojor Onwuka, Florence Guida, Ryan Langdon, Mikael Johansson, Gianluca Severi, Roger L Milne, Pierre-Antoine Dugué, Melissa C Southey, Paolo Vineis, Torkjel Sandanger, Therese Haugdahl Nøst, Marc Chadeau-Hyam, Caroline Relton, Hilary A. Robbins, Matthew Suderman, Mattias Johansson
21 May 2024open access icon
Patterns of cytotoxic T-cell densities in immunogenic endometrial cancers reveal a potential mechanism for differences in immunotherapy efficacy
Neil Ryan, Mark Glaire, Thomas Walker, Natalja ter Haar, Marieke Ijsselsteijn, James Bolton, Noel de Miranda, Gareth Evans, David N Church, Tjalling Bosse, Emma Crosbie
15 May 2024open access icon
Exploring the value of routinely collected data on EQ-5D-5L and other electronic patient-reported outcome measures as prognostic factors in adults with advanced non-small cell lung cancer receiving immunotherapy
Kuan Liao, David C Wong, Fabio Gomes, Corinne Faivre-Finn, Laura Moliner, Matthew Sperrin, Janelle Yorke, Sabine N van der Veer
9 May 2024open access icon
First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours
Aung Naing, Kyriakos P Papadopoulos, Michael J Pishvaian, Osama Rahma, Glenn J Hanna, Elena Garralda, Omar Saavedra, Sven Gogov, Howard Kallender, LuLu Cheng, Michael Smith, Xuejun Chen, Emil Kuriakose, Todd Bauer
8 May 2024open access icon
Defining national research priorities for prostate cancer in Zambia: using the Delphi process for comprehensive cancer policy setting in sub-Saharan Africa
Dorothy Chilambe Lombe, Monde Mwamba, Musonda Simwinga, Virginia Bond, Andrew Sentoogo Ssemata, Richard Muhumuza, Janet Seeley, Kennedy Lishimpi, Victor Mapulanga, John Kachimba, Ajay Aggarwal, Susan Msadabwe
30 April 2024open access icon
Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis
Elias B A Chandran, Giovanni Maria Iannantuono, Saad O Atiq, Dilara Akbulut, Ninet Sinaii, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Amin H Nassar, Jonathan E Rosenberg, Gisela Butera, Min Yuen Teo, Guru Sonpavde, Jonathan A Coleman, Andrea B Apolo
18 April 2024open access icon
Sex and authorship in global cancer research
Miriam Mutebi, Grant Lewison, Deborah Mukherji, Nazik Hammad, Verna Vanderpuye, Erica Liebermann, Winnie K W So, Julie Torode, Richard Sullivan, Ophira Ginsburg
11 April 2024open access icon
Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials
Alexander D Sherry, Pavlos Msaouel, Timothy A Lin, Joseph Abi Jaoude, Ramez Kouzy, Esther J Beck, Avital M Miller, Adina H Passy, Gabrielle S Kupferman, Eugene J Koay, Clifton David Fuller, Charles R Thomas, Zachary R McCaw, Ethan B Ludmir
8 April 2024open access icon
Characterisation of clinical response and transcriptional profiling of proliferating CD8 T cells in the blood of cancer patients after PD-1 monotherapy or combination therapy
Rebecca C Obeng, Tahseen H Nasti, Kylee Martens, Peng Li, Annapaola Mariniello, Daniel Y Chang, Christiane S Eberhardt, Donald McGuire, Haydn Kissick, Candace Daugherty, Yuzi Zhang, Andreas Wieland, Zhengjia Chen, Jeffrey M Switchenko, Rathi Pillai, Alice O Kamphorst, Warren J Leonard, Rafi Ahmed, Suresh S Ramalingam
3 April 2024open access icon
Tale of two zones: investigating the clinical outcomes and research gaps in peripheral and transition zone prostate cancer through a systematic review and meta-analysis
Amin Ali, Thiraviyam Elumalai, BhanuPrasad Venkatesulu, Lauren Hekman, Hitesh Mistry, Ashwin Sachdeva, Pedro Oliveira, Noel Clarke, Esther Baena, Ananya Choudhury, Robert G Bristow
19 March 2024open access icon
Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials
Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Ryan McIntire, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia, Alyson Haslam, Vinay Prasad, Matt Vassar
13 March 2024open access icon
Feasibility of implementing a rapid-learning methodology to inform radiotherapy treatments: key professional stakeholders’ views
Arbaz Kapadi, Gareth Price, Corinne Faivre-Finn, Rebecca Holley, Kate Wicks, Kathryn Banfill, Gareth Webster, Kevin Franks, Fiona McDonald, Daniel Johnson, David P French
12 March 2024open access icon
Challenges faced by women oncologists in Africa: a mixed methods study
Miriam Mutebi, Naa Adorkor Aryeetey, Haimanot Kasahun Alemu, Laura Carson, Zainab Mohamed, Zainab Doleeb, Nwamaka Lasebikan, Nazima Jaffer Dharsee, Susan Msadabwe, Doreen Ramogola-Masire, Sitna Mwanzi, Khadija Warfa, Emmanuella Nwachukwu, Edom Seife Woldetsadik, Hirondina Vaz Borges Spencer, Nesrine Chraiet, Matthew Jalink, Reshma Jagsi, Dorothy Chilambe Lombe, Verna Vanderpuye, Nazik Hammad
29 February 2024open access icon
Comparison of standard-dose and reduced-dose treatment of metastatic prostate cancer with enzalutamide, apalutamide or darolutamide: a rapid review
Hannah Louise Bromley, Mohini Varughese, Duncan C Gilbert, Peter Hoskin, Ian F Tannock, Kimberley Reeves, Ananya Choudhury
10 February 2024open access icon
Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia
Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Marie Roumet, Andreas Limacher, Herbert Kapesa, Thamsanqa Madliwa, Anne Rutjes, Partha Basu, Nicola Low, Albert Manasyan, Julia Bohlius
1 February 2024open access icon
Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy
Jian-Guo Zhou, Jie Yang, Haitao Wang, Ada Hang-Heng Wong, Fangya Tan, Xiaofei Chen, Si-Si He, Gang Shen, Yun-Jia Wang, Benjamin Frey, Rainer Fietkau, Markus Hecht, Wenzhao Zhong, Hu Ma, Udo Gaipl
30 January 2024open access icon
Pharmacological class effects of anticancer drugs: opportunities for decreasing healthcare spending
Daniel A Goldstein, Leonard B Saltz, Gregory R Pond, Ian F Tannock
9 January 2024open access icon
Novel proteomics-based plasma test for early detection of multiple cancers in the general population
Bogdan Budnik, Hossein Amirkhani, Mohammad H Forouzanfar, Ashkan Afshin

Review

10 September 2024open access icon
Circulating tumour cell clusters: isolation, biological significance and therapeutic implications
Yufan Yang, Guanyin Huang, Jingru Lian, Chunhao Long, Boxi Zhao, Xuefei Liu, Binyu Zhang, Weijian Ye, Junhao Chen, Longxiang Du, Zhuofeng Jiang, Jialing Liu, Jianglin Zhang, Chengzhi Hu, Qingfeng Chen, Xin Hong
16 July 2024open access icon
Association between rheumatoid arthritis and risk of radiotherapy toxicity: a systematic review
Nina Liebenberg, Alan McWilliam, Sarah L Kerns, Deborah C Marshall, Catharine M West
31 May 2024open access icon
Implications of hormonal carcinogenesis for transgender and gender-diverse people undergoing gender-affirming hormone therapy: an up-to-date review
Alberto Giovanni Leone, Stefania Bonadonna, Chiara Cassani, Amelia Barcellini, Marianna Sirico, Barbara Tagliaferri, Stefano Maccarone, Davide Dalu, Lorenzo Ruggieri, Filippo Ghelardi, Matteo Lambertini, Simone Nardin, Rossana Berardi, Nicla La Verde, Francesco Perrone, Saverio Cinieri, Dario Trapani, Filippo Pietrantonio
10 May 2024open access icon
Prospective evaluation of artificial intelligence (AI) applications for use in cancer pathways following diagnosis: a systematic review
Sheba Macheka, Peng Yun Ng, Ophira Ginsburg, Andrew Hope, Richard Sullivan, Ajay Aggarwal
17 January 2024open access icon
Repurposing radiosensitising medicines for radiotherapy: an overview
Jie Man Low, Gonzalo Rodriguez-Berriguete, Geoff S Higgins
17 January 2024open access icon
Artificial intelligence across oncology specialties: current applications and emerging tools
John Kang, Kyle Lafata, Ellen Kim, Christopher Yao, Frank Lin, Tim Rattay, Harsha Nori, Evangelia Katsoulakis, Christoph Ilsuk Lee